I downloaded the basic RegSupreme 1.7.0.416 tonight and it wouldn't start on my Windows ME computer. Same problem as listed above, "it is visible in the task bar next to start for a very short time and then disappears".
I did notice that when installed, 1.7.0.416 didn't create a "Data" folder in its program folder.
Personally, for me I'm not complaining. It is an old operating system. I just went back to the last version I had burned to disc - ver. 1.4.0.46.