Nope;
1. The "Never Show Again" works in jv16PT v.413, and RegSupremePro v.414 and doesn't stop working until I "update" to the v.416.
2. I don't know what you'd consider "very large" but my SuperRegIgnoreList.dat is 5k and contains 44 entries, and the exact same file worked just fine before "updating".
3. The entries I want ignored are in the SuperRegIgnoreList.dat, it's just that the RegCleaners aren't ignoring them.
The Never Show Again worked just fine until it was "fixed". Maybe it should be unfixed.