I have been trying to use RegSupreme Pro with Vista Premium and it only works if you check the compatibility box for SP2. Afterwhich it starts to work but only for a while. Everytime I get a big warning boxs with a red x when trying to use the program. The program never comes backup after using it for about once or twice. What is the problem. It seems to work for the period of time when it is working but as I stated. It won't come back up after a few times just a red x showing that I can't access the program anymore.