I installed and ran the beta program, and then found like 4000+ items on the regular scan. I fixed them all and then rebooted. After rebooting, it entirely destroyed my fonts, removing them all and giving me a bunch of symbols in place of the English words that should have been there. There wasn't a single word or letter anywhere on screen. It looked like wingdings was everywhere, but it was mostly placeholder boxes and question marks and other weird symbols. I had to get another computer to run RegSupreme to see how to restore backups. Restoring it fixed it. I did notice that on the list of items scanned, that two fonts were listed. I know one of them was "Arial Bold" but I can't recall what the other was (at work atm). If you need more info, I can give it after I get home.
I also ran it on another PC to see what would happen, and it deleted the functionality of the programs area of the start bar. Not only did it delete the computer's start->programs menu, it made it not work to make new ones or drag anything into it. Searching revealed a few of the program folders remained, but the majority of them had been deleted. In this instance, restoring the backups did not repair the problem. I had to use a Windows Defender restore point to fix the program portion of the startbar.
Needless to say, the glowing reviews I read on tweaksrus.com didn't exactly convey how much trouble the scan could cause. The first PC didn't have the startbar problem, and the 2nd pc didn't have the screwed up font problem.
Both run Win XP SP2, fully updated thru Windows Update.