The issue involves a single HKCU key (HKEY_CURRENT_USER\Software\Microsoft\DirectInput\MostRecentApplication\). The HKUS key mirrors the HKCU key.
Likely causes:
1. Either DXDIAG.EXE established a startup task running in the background with a lock on the key
2. Or Microsoft Direct Input created the key with permissions and/or ownership that won't allow Administrators (thus PowerTools) to control the key
3. Or both 1 and 2
4. Or something else. For example, a Microsoft Direct Input process or service is always running with a lock on the key.
Corrective action suggestions:
1. For cause #1, use the PowerTools Startup Manager to look for a DXDIAG related startup task. If you find it, disable or remove it and reboot.
2. For cause #2, use RegEdit to change the key's permissions and/or ownership. http://www.macecraft.com/phpBB3/viewtopic.php?p=20992#p20992 shows a way to do that.
3. For cause #3, do 1 and 2.
4. For cause #4, put DXDIAG.EXE in the Ignore words tab. Also, do this if you don't want to try the other corrective actions.