PowerTools 2006 isn't Vista ready.
The new 2007 version will work better on it.
Also be aware that if you are running a 64Bit version of Windows (XP or Vista), that PowerTools won't work as excepected.
It will find key's that are correct, but not detectable by PowerTools.
Also, i havent tryed it my self.
So i will check if i have drag/drop support on my Vista machine.